CytoTronics, Inc.
Pixel Systems – Visualize live cell function at scale
Pixel™ enables high-resolution, multiplexed, real-time assessment of live-cell characteristics, providing deeper understanding of how chemical or genetic perturbation affect cell function.
The Pixel System
Applications
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Cancer Cell Biology
Explore cancer cell behavior through changes in cell viability, migration, in vitro metastasis assays and immuno-oncology applications. -
Cardiac Function
Enhance cardiotoxicity studies by enabling simultaneous assessment of both structural and functional toxicity. Model cardiac diseases by measuring interactions between diverse cell populations. -
Endothelial and Epithelial Cells
Achieve unparalleled accuracy in real-time monitoring of barrier formation, wound healing, and migration in cell sheets. This capability finds applications in studying intestinal barriers, endothelial cell function and blood-brain barrier studies. -
Neuron Function
Investigate neuron function at a single-cell resolution using customizable stimulation protocols. Simultaneously measure extracellular action potential, cell viability, morphology, and metabolism. -
Stem Cell Biology
Utilize label-free measurements for continuous monitoring of morphological and functional features of cells over extended periods, spanning days and weeks. Evaluate the pluripotency of cells and track their differentiation into various lineages. -
Mechanism of Action/Toxicology
Leverage multi-parametric measurements to generate phenotypic signatures linked to cellular pathways. Identify mechanisms of action (MoAs), fine-tune Structure-Activity Relationship (SAR) studies, and promptly eliminate off-target effects.
A breakthrough in semiconductor-to-cell-biology interface
CytoTronics takes traditional electrode-based measurements to unprecedented levels of accuracy and scale using microelectrode arrays and integrated circuits to assess live cell functions in real time at single-cell resolution.
Powered by microchips
At the core of the Pixel system is a proprietary microplate embedded with custom-designed semiconductor microchips at the base, providing thousands of measurement and stimulation electrodes in each well. The electrodes can monitor cell viability, morphology, electrophysiology, metabolism, and more while generating electrical images of single-cell spatial resolution. The system is designed for ease of use by enabling plating of any cell type with a wide range of biological coatings.
Monitor cell behavior in real-time
The Pixel Pro cloud-based application software is designed for interactive analysis and reporting. With the Pixel System, scientists can quickly assess data obtained from every scan to reveal a more complete picture of cell behavior.
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Resources
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